If traveling with your own car leave Asuncion via Mariano Roque Alonso and pass the Rio Paraguay on the Remanso bridge. Follow the road no. 9, the Transchaco highway, until kilometer 440, where the access road to Filadelfia starts and leads you after 16 kilometers directly into the center of the city via Avenida Hindenburg where Hotel Florida is situated at the right side of the lane.
Also it's possible to arrive by a non-stop bus leaving the international bus terminal of Asuncion. The buses of all companies stop in front of Hotel Florida.